The Effects of Honey Compared With Sucrose and a Sugar-free Diet on Neutrophil Phagocytosis and Lymphocyte Numbers after Long-term Feeding in Rats
Abstract+
To determine whether honey and sucrose would have differential effects on levels of neutrophil phagocytosis after long-term feeding 36 2-month old Sprague Dawley rats were fed a powdered diet that was either sugar-free or contained 7.9% sucrose or 10% honey (honey is 21% water) ad libitum for 52 weeks. The percent of neutrophils exhibiting phagocytosis, and the percentage of leukocytes that were lymphocytes were then measured by flow cytometry after 52 weeks. Results: Neutrophil phagocytosis was similar between sucrose- and honey-fed rats, and lower in rats fed the sugar-free diet (79.2%, 74.7% and 51.7 %, respectively). The percentage of leukocytes that were lymphocytes differed significantly between all three treatments, the levels being highest in honey-fed rats (53% vs 40.1% and 29.5% for sucrose- and sugar-free fed rats). In conclusion: Honey may have a beneficial effect on immune activity, possibly attenuating the decline seen in older age.Submitted: September 11, 2007 · Accepted: October 11, 2007 · Published: October 14, 2007
Recommended Citation
Chepulis, Lynne M. (2007) "The Effects of Honey Compared With Sucrose and a Sugar-free Diet on Neutrophil Phagocytosis and Lymphocyte Numbers after Long-term Feeding in Rats," Journal of Complementary and Integrative Medicine: Vol. 4 : Iss. 1, Article 8.Available at: http://www.bepress.com/jcim/vol4/iss1/8
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